The Robert B. Marquis Collection spans the years 1953-1994, and is organized into four series: Personal Papers, Professional Papers, Office Records and Project Records. The Collection documents his career beginning with single-family homes, mainly of wood and in a mid-century modern style, in the 1950s and 1960s, through larger commercial, government and educational projects in the 70s, 80s and 90s. The documentation of his work rehabilitating and planning public housing projects is particularly strong.

The few Personal Papers contain student drawings, Marquis's CV, and negatives of personal photographs. The Professional Papers consist of five folders of transcripts and outlines for lectures, with related correspondence and clippings. These materials provide insight into Marquis's architectural philosophy. Office Records contain correspondence, public relations material, project portfolios and photographs. The most significant materials in the Office Records are files of design notes, and extensive documentation of completed projects including photographs, slides, clippings of articles about specific projects, and project descriptions.

The Project Records contain drawings, specifications, and correspondence relating to projects throughout Marquis's career. The bulk of the Series covers numerous Bay Area public housing projects; San Francisco International Airport; as well as community and educational buildings, notably the Braun Music Center and revisions to the Green library at Stanford, the Aaron Copeland School of Music at Queens College in New York, and the music building at CSU Fresno. There are also materials on the Visitor's Center for Lawrence Halprin's Franklin Delano Roosevelt Memorial in Washington, D.C.