The collection, which spans the years 1930-1978 (bulk 1954-1968), consists of records, drawings, photographs, and papers relating to the architectural career of Germano Milono. Working mostly in California and Nevada, Germano Milono and Associates took on educational, civic, commercial, medical, religious, planning and single-family residential projects. The firm collaborated with structural engineer, T.Y. Lin and landscape architect, Thomas D. Church.

Major educational projects include renovations to several buildings on the University of California, Berkeley campus, including California Hall, Moses Hall, and Stephens Halls. The collection also includes his work for the new UC Santa Cruz campus Social Sciences Building and Sonoma State College Library. Milono also worked extensively on the Santa Catalina School for Girls in Monterey, California.

Notable religious projects include the Church of the Good Shepherd in Corral de Tierra, California, Holy Name Parish Hall in San Francisco, and St. John the Baptist Church in Napa, California. Milono also participated in several civic projects. Notable residential projects include the Gauer House, Sonoma County, California, the Kelly House, Santa Rosa, California, the Honig House in Inverness, California, and the Foster House in Pebble Beach, California.